Side Effects after mRNA COVID-19 Vaccine as a Booster in Health Workers

Background: In Indonesia, around 400 health workers died due to Covid-19 between June-July 2021, therefore the health workers need to be given further immunity. Health workers were among the first to get a booster shoot. However, they may experience side effects after vaccination. We aimed to describe side effects of Moderna vaccine as a booster in health workers.Methods: A cross sectional study was conducted on health workers who received mRNA Covid-19 vaccine booster (Moderna) at Sulianti Saroso Infectious Disease Hospital, Indonesia and had filled the questionnaire assessing side effects form. We associated the form of the questionnaire assessing side effects from the originat-ing source of hospital immunization unit in September 2021.Results: A total of 101 health workers who received mRNA Covid-19 vaccine booster in Jul-Aug 2021 were included. Most of health worker experienced more than 3 side effects. The side effects were sore arm (100%);chills (72%);fatigue (57%);headache (53%) and fever (51%), other symptoms (28%). The side effects mostly happened a day of receiving a booster shot (61.4%). There was no association between age, gender, comorbid to amount of side effects (P>0.05).Conclusion: Since the public must fulfil the immunization program during pandemic, it is the responsibility of the healthcare provider to inform about the potential side effects and benefits of a new Covid-19 vaccine.

Quantitative Antibody Levels in Hospital Workers after Receiving three Doses of CoviD-19 vaccines

Hospital workers were at high risk for SARS-Cov-2 infection and the first population with authorized access to the three doses of vaccination against SARS-Cov-2 antigen. The study was aimed to compare SARS-Cov-2 antibody levels among hospital workers receiving the three doses of Covid-19 vaccines with a history of Covid-19 infection versus those without a history of infection. A cross sectional study was conducted at the Sulianti Saroso infectious Disease Hospital (SSiDH) in December 2021. The inclusion criteria were hospital workers in both subjects with and without previous Covid-19 infection and those who had received 3 doses of Covid-19 vaccines. Anti SARS-Cov-2 antibody levels measured by the Architect of SARS-Cov-2 igG ii Quant. There were 75 participants in the study, the median of anti SARS Cov-2 levels reported 8724.4 AU/mL (3396.8, 15773.2 AU/mL, interquartile range). They were divided into 2 groups according to the status of prior Covid-19 infection, hospital workers with and without previous of Covid-19 infection. There was no significance difference in antibody less than 25.000 AU/mL between hospital worker with and without previous Covid-19 infection (p=1,000). Meanwhile, the median of antibody levels was seen in the interval between the 3rd dose of vaccine within 1 month;2 to 3 months;4 to 5 months before the antibody measurement (14576.5 AU/mL;12407.4 AU/mL;5778.1 AU/mL, respectively). in this study, after three doses of Covid-19 vaccines, there was no significance difference in antibody levels of hospital worker with and without previous Covid-19 infection. Copyright © 2022 Oriental Scientific Publishing Company. All rights reserved.